Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages.
نویسندگان
چکیده
SOD-mimics are small complexes that reproduce the activity of superoxide dismutases, natural proteins that catalytically dismutate the superoxide anion. Activated macrophages, which produce ROS and RNS fluxes, constitute a relevant model to challenge antioxidant activity in a cellular context and were used to test a Mn-complex which was shown to efficiently alter the flow of O(2)(-), ONOO(-) and H(2)O(2).
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عنوان ژورنال:
- Dalton transactions
دوره 41 21 شماره
صفحات -
تاریخ انتشار 2012